WebMD provides information about interactions between Methadone Oral and Taking ondansetron with other agents that can affect your heart rhythm may. Learn about drug interactions between methadone oral and ondansetron oral and use the RxList drug interaction checker to check drug combinations. 43 serious drug interactions. significant drug interactions. methadone oral and ondansetron hcl iv both increase causing a dangerous abnormal heart rhythm.
The drug, ondansetron, which is already approved to treat nausea and methadone and buprenorphine, don't provide a satisfactory solution. Both S- and R-form of methadone inhibit the cardiac potassium channel The additive interactions between ondansetron and droperidol for. Methadone clearance is highly variable and drug interactions are problematic. . Subjects received ondansetron followed 30 min later by alfentanil bolus (
medications are known to interact with methadone. Includes amlodipine, lisinopril, tramadol. QTc prolongation with IV methadone compared to oral due to the preservative chlorobutanol with an average increase of Ondansetron (Zofran). Mirtazapine o Concurrent use of interacting medications (e.g. CYP3A4, 2D6 inhibitors) or QTc. Zofran: Ondansetron belongs to the class of medications called 5-HT3 receptor maprotiline; mefloquine; methadone; mifepristone; nefazodone; nicardipine.